Showing posts with label likely. Show all posts
Showing posts with label likely. Show all posts

Tuesday, 30 July 2013

Female deaths much less likely to be reported to coroner in England and Wales, UK

Main Category: Women's Health / Gynecology
Article Date: 30 Jul 2013 - 0:00 PDT Current ratings for:
Female deaths much less likely to be reported to coroner in England and Wales, UK
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Doctors in England and Wales are much less likely to report a woman's death to a coroner than they are a man's, reveals research published online in the Journal of Clinical Pathology.

Furthermore, women's deaths are less likely to proceed to an inquest, and those that do are less likely to result in a verdict of "unnatural" death than men's, with some coroners particularly likely to favour a verdict according to the sex of the deceased, the research shows.

The authors analysed figures from the Ministry of Justice on the numbers and proportions of deaths reported to all 98 coroners, in each of the 114 jurisdictions in England and Wales, between 2001 and 2010.

These figures were then set in the context of official national statistics on the number of deaths registered in England and Wales over the same period.

Doctors are not obliged to report a death to a coroner, and the legal duty to hold an inquest resides with the coroner, usually prompted by a death in unnatural or violent circumstances, or when the death is sudden, of unknown cause, or happens in prison.

The analysis of the figures showed that coroner reporting rates varied widely across England and Wales.

Plymouth and South West Devon topped the league table, with 87% of registered deaths reported to the coroner between 2001 and 2010, while Stamford in Lincolnshire came bottom, with only 12% of deaths reported to the coroner.

There were no obvious explanations to account for such wide differences, which remained stable throughout the decade, suggesting that local demographics or medico-legal practice had a part to play, say the authors.

Similarly, coroners varied widely in their use of verdicts, which again remained consistent over time, the analysis showed. This is likely to reflect the personal decision making style of the coroner rather than any local patterns in deaths, say the authors.

But when they looked at reporting rates according to the sex of the dead person, a striking gender divide emerged.

While jurisdictions with high reporting rates for men also had high reporting rates for women, and vice versa, male deaths were 26% more likely to be reported to the coroner than female deaths.

Higher reporting rates for men were common across all jurisdictions in England and Wales, and in some areas male deaths were 48% more likely to be reported.

Not only were female deaths less likely to be reported, but they were also less likely to proceed to an inquest.

Female deaths were half as likely to proceed to an inquest as men's, with just 8% going to this stage compared with 16% of all male deaths. And even when female deaths did get an inquest, they were more likely to be given a verdict of natural causes than men (28% compared with 22%).

Among verdicts of unnatural deaths, men were overrepresented in occupational diseases and suicide while women were overrepresented in narrative verdicts - where cause of death is given in the form of a narrative rather than as a single "short form" definition - and accidents, implying that sex of the deceased influences the verdict, say the authors.

Furthermore, some coroners were "gendered," in their approach to inquest verdicts, and more likely to favour a particular verdict when dealing with a death, according to the gender of the deceased.

The government is currently reforming the death certification process in a bid to strengthen arrangements and improve the quality and accuracy of causes of death, but there are some concerns that the move will prompt a fall in deaths reported to the coroner from the present national average of 46% to around 35%, say the authors.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our women's health / gynecology section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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30 Jul. 2013. APA

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'Female deaths much less likely to be reported to coroner in England and Wales, UK'

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Teens' kidney transplants more likely to fail

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Academic Journal
Main Category: Transplants / Organ Donations
Article Date: 30 Jul 2013 - 0:00 PDT Current ratings for:
Teens' kidney transplants more likely to fail
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Adolescents who have their first kidney transplant between 14 and 16 years of age could have a higher risk of transplant failure, according to a study published in the journal JAMA Internal Medicine.

Researchers from the University of Florida, Gainesville, analyzed 168,809 patients between 1987 and 2010. All participants had their first kidney transplant and their ages ranged up to 55.

Data was analyzed from the Organ Procurement Transplantation Network Standard Transplant Analysis and Research Database.

The study population characteristics analyzed in the study included the recipients' sex, race and insurance type, and the donors' living vs deceased status, sex, health and their combined Human Leukocyte Antigens (HLA) match information.

Results of the study showed that patients aged between 14 and 16 years had the highest risk of graft loss of all age groups.

The researchers found that graft loss started at 1 year after the transplant was carried out, and increased at 3-, 5- and 10-year points.

The study also revealed that black adolescents have an even higher risk of graft failure, compared with non-black adolescents.

The study authors say that using age at transplant as the risk factor, there was a decreasing relative hazard of graft failure in different insurance groups.

The researchers found the following range, in order of highest to lowest, for graft failure risk:

Deceased donor - government insurance groupDeceased donor - private insurance groupLiving donor - government insurance groupLiving donor - private insurance group

They add that in the death-censored analysis, this order of risk was consistent from infancy to 55 years of age.

Additionally, the results showed that among 14-year-old patients, there was an increased death risk of 175% in the deceased donor-government insurance group, compared with the living donor-private insurance group.

The researchers conclude that comprehensive programs are needed for adolescent transplant recipients, as current medical literature "does not adequately describe the risks of graft failure among kidney transplant recipients by age."

They say: "The realization that this age group is at an increased risk of graft loss as they are becoming young adults should prompt providers to give specialized care and attention to these adolescents in the transition from pediatric to adult-focused care."

The researchers conclude:

"Implementing a structured health care transition preparation program from pediatric to adult-centered care in transplant centers may improve outcomes."

Written by Honor Whiteman


Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our transplants / organ donations section for the latest news on this subject.

"Age-related kidney transplant outcomes health disparities amplified in adolescence," JAMA Internal Medicine, July 29, 2013.

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Treatments for tuberculosis, cancer will likely improve following breakthrough in detecting DNA mutations

Main Category: Tuberculosis
Also Included In: Cancer / Oncology;  Genetics
Article Date: 30 Jul 2013 - 0:00 PDT Current ratings for:
Treatments for tuberculosis, cancer will likely improve following breakthrough in detecting DNA mutations
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The slightest variation in a sequence of DNA can have profound effects. Modern genomics has shown that just one mutation can be the difference between successfully treating a disease and having it spread rampantly throughout the body.

Now, researchers have developed a new method that can look at a specific segment of DNA and pinpoint a single mutation, which could help diagnose and treat diseases such as cancer and tuberculosis. These small changes can be the root of a disease or the reason some infectious diseases resist certain antibiotics. The findings were published online in the journal Nature Chemistry.

"We've really improved on previous approaches because our solution doesn't require any complicated reactions or added enzymes, it just uses DNA," said lead author Georg Seelig, a University of Washington assistant professor of electrical engineering and of computer science and engineering. "This means that the method is robust to changes in temperature and other environmental variables, making it well-suited for diagnostic applications in low-resource settings."

DNA is a type of nucleic acid, the biological molecule that gives all living things their unique genetic signatures. In a double strand of DNA, known as a double helix, a series of base pairs bond and encode our genetic information. As genomics research has progressed, it's clear that a change of just one base pair - a sequence mutation, an insertion or a deletion - is enough to trigger major biological consequences. This could explain the onset of disease, or the reason some diseases don't respond to usual antibiotic treatment.

Take, for example, tuberculosis ?" a disease that's known to have drug-resistant strains. Its resistance to antibiotics often is due to a small number of mutations in a specific gene. If a person with tuberculosis isn't responding to treatment, it's likely because there is a mutation, Seelig said.

Now, researchers have the ability to check for that mutation preventatively.

Seelig, along with David Zhang of Rice University and Sherry Chen, a UW doctoral student in electrical engineering, designed probes that can pick out mutations in a single base pair in a target stretch of DNA. The probes allow researchers to look in much more detail for variations in long sequences - up to 200 base pairs ?" while current methods can detect mutations in stretches of up to only 20.

"In terms of specificity, our research suggests that we can do quadratically better, meaning that whatever the best level of specificity, our best will be that number squared," said Zhang, an assistant professor of bioengineering at Rice University.

The testing probes are designed to bind with a sequence of DNA that is suspected of having a mutation. The researchers do this by creating a complimentary sequence of DNA to the double-helix strand in question. Then, they allow molecules containing both sequences to mix in a test tube in salt water, where they naturally will match up to one another if the base pairs are intact. Unlike previous technologies, the probe molecule checks both strands of the target double helix for mutations rather than just one, which explains the increased specificity.

The probe is engineered to emit a fluorescent glow if there's a perfect match between it and the target. If it doesn't illuminate, that means the strands didn't match and there was in fact a mutation in the target strand of DNA.

The researchers have filed a patent on the technology and are working with the UW Center for Commercialization. They hope to integrate it into a paper-based diagnostic test for diseases that could be used in parts of the world with few medical resources.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our tuberculosis section for the latest news on this subject.

The research was funded by the National Institutes of Health, the National Science Foundation and the Department of Defense's Advanced Research Projects Agency.

University of Washington

Please use one of the following formats to cite this article in your essay, paper or report:

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University of Washington. "Treatments for tuberculosis, cancer will likely improve following breakthrough in detecting DNA mutations." Medical News Today. MediLexicon, Intl., 30 Jul. 2013. Web.
30 Jul. 2013. APA

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'Treatments for tuberculosis, cancer will likely improve following breakthrough in detecting DNA mutations'

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Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here

Thursday, 25 July 2013

People who carry a particular gene allele APOE4 can be over 10 times more likely to develop late-onset Alzheimer's disease

Main Category: Alzheimer's / Dementia
Also Included In: Neurology / Neuroscience
Article Date: 24 Jul 2013 - 10:00 PDT Current ratings for:
People who carry a particular gene allele APOE4 can be over 10 times more likely to develop late-onset Alzheimer's disease
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The molecular pathway linking a genetic variant to the common, non-familial form of Alzheimer's disease is revealed in Nature this week. The study boosts our knowledge of the pathology of this neurodegenerative disease, and hints at new directions for therapy.

People who carry a particular gene allele APOE4 can be over 10 times more likely to develop late-onset Alzheimer's disease (LOAD). Asa Abeliovich and colleagues now show that the pattern of gene expression in the brains of APOE4 carriers has similarities to the patterns of gene expression in LOAD patients, and suggest that this altered profile might be an early hallmark of the disease. They identify a handful of genes thought to regulate this unusual transcription profile, including novel and previously known regulators of the amyloid precursor protein (APP), a molecule that has long been implicated in Alzheimer's disease. Genetic variants found at two of the genes may even affect the age when LOAD may set in.

Finally, the team tested a possible therapy, the drug levetiracetam, which inhibits one of the genes identified, and is currently used clinically to treat seizures. The drug suppresses APP processing in cells cultured from APOE4 carriers, making it a molecule worthy of further study.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our alzheimer's / dementia section for the latest news on this subject. Please use one of the following formats to cite this article in your essay, paper or report:

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Nature. "People who carry a particular gene allele APOE4 can be over 10 times more likely to develop late-onset Alzheimer's disease." Medical News Today. MediLexicon, Intl., 24 Jul. 2013. Web.
24 Jul. 2013. APA

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'People who carry a particular gene allele APOE4 can be over 10 times more likely to develop late-onset Alzheimer's disease'

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Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.



View the original article here