Showing posts with label Better. Show all posts
Showing posts with label Better. Show all posts

Tuesday, 30 July 2013

Children who use gestures tend to perform better on cognitive tasks

Main Category: Psychology / Psychiatry
Also Included In: Pediatrics / Children's Health
Article Date: 30 Jul 2013 - 0:00 PDT Current ratings for:
Children who use gestures tend to perform better on cognitive tasks
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In the first study of its kind, SF State researchers have shown that younger children who use gestures outperform their peers in a problem-solving task.

The task itself is relatively simple -- sorting cards printed with colored shapes first by color, and then by shape. But the switch from color to shape can be tricky for children younger than 5, says Professor of Psychology Patricia Miller.

In a new study due to be published in the August, 2013 issue of Developmental Psychology, Miller and SF State graduate student Gina O'Neill found that young children who gesture are more likely to make the mental switch and group the shapes accurately.

In fact, gesturing seemed to trump age when it came to the sorting performance of the children, who ranged from 2 and a half years old to 5 years old. In the color versus shape task, as well as one that asked children to sort pictures based on size and spatial orientation, younger children who gestured often were more accurate in their choices than older children who gestured less. The children's gestures included rotating their hands to show the orientation of a card or using their hands to illustrate the image on the card, for example gesturing the shape of rabbits' ears for a card depicting a rabbit.

"Gina and I were surprised by the strength of the effect. Still, the findings are consistent with a growing body of research showing that mind and body work closely together in early cognitive development," Miller said.

"The findings are a reminder of how strong individual differences are among children of a particular age," she added. "Certain 3-year-olds look like typical 4-year-olds. This likely reflects an interaction of natural talent and particular experiences -- both nature and nurture, as usual."

There is a growing body of research that suggests gesturing may play a significant role in the processes that people use to solve a problem or achieve a goal. These processes include holding information in memory, keeping the brain from choosing a course too quickly and being flexible in adding new or different information to handle a task.

Studies have shown that gesturing can help older children learn new math concepts, for example. "Really, though, there is evidence that gesturing helps with difficult cognitive tasks at any age," Miller said. "Even we adults sometimes gesture when we're trying to organize our tax receipts or our closets. When our minds are overflowing we let our hands take on some of the cognitive load."

O'Neill and Miller observed the children's spontaneous gestures as they performed the tasks, as well as gestures they were encouraged to make to explain their sorting choices. Both kinds of gestures were counted in comparing high and low gesturing children.

Children who did a lot of gesturing did better at the sorting task than those who didn't gesture as much -- even when they did not use gesturing during the task itself, the researchers found. This makes it difficult to determine whether it's the gesturing itself that helps the children perform the task, or whether children who use a lot of gestures are simply at a more advanced cognitive level than their peers. It is a question that Miller hopes to answer in further studies.

Miller said there is "quite a bit of evidence now that gestures can help children think," perhaps by helping the brain keep track of relevant information or by helping the brain reflect on the possibilities contained within a task. "In my opinion, children shouldn't be discouraged from gesturing when they want to gesture during learning," she said. "Adults sometimes -- appropriately -- say to children, 'use your words,' but some children may think this applies to all situations."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our psychology / psychiatry section for the latest news on this subject.

The study, "A Show of Hands: Relations between Young Children's Gesturing and Executive Function," will be published in the August, 2013 issue of the journal Developmental Psychology.

San Francisco State University

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Restless legs syndrome: Study raises hope for better drugs

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Main Category: Restless Legs Syndrome
Also Included In: Neurology / Neuroscience
Article Date: 30 Jul 2013 - 8:00 PDT Current ratings for:
Restless legs syndrome: Study raises hope for better drugs
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John Hopkins researchers may have discovered why insomnia persists in patients with restless legs syndrome (RLS), despite successful treatment of the condition. 

People with restless legs syndrome, sometimes called "jimmy legs," have an uncontrollable urge to move their legs. The condition varies in severity and can be painful, distressing and interrupt daily activities as well as disturb sleep. 

In spite of effective drugs to relieve RLS, studies have shown that they do not improve sleep outcomes and only treat the restless legs. 

A research team led by Dr. Richard Allen, associate professor of neurology at John Hopkins University School of Medicine, has looked into solving the sleep anomaly, using MRI to image the brain in a group of 28 RLS patients and 20 non-RLS patients. 

Glutamate, the neurotransmitter involved in arousal, was found in abnormally high levels in the RLS group. The higher the level of glutamate recorded in the brain of those with RLS, the worse the patient's sleep. 

The research team recorded MRI images and glutamate activity in the thalamus - the part of the brain involved with the regulation of consciousness, sleep and alertness. 

RLS patients included in the study had severe symptoms: 

On six or seven nights a weekPersisting for at least six monthsWith an average of at least 20 involuntary movements a night.

The second stage of the experiment involved a two-day sleep study. RLS patients were reported to have received 5.5 hours sleep on average. The researchers identified a direct link in this group between glutamate levels in the thalamus and the number of hours of sleep. There was no such association in the non-RLS control group. 

Dr. Richard Allen is hopeful that the team may have discovered the reason why restless legs syndrome also affects sleep. He says:

"We may have solved the mystery of why getting rid of patients' urge to move their legs doesn't improve their sleep.

We may have been looking at the wrong thing all along, or we may find that both dopamine and glutamate pathways play a role in RLS."

The results of the study could lead to developments in the way RLS is treated, potentially helping to eradicate sleepless nights for people with restless legs syndrome. 

Dopamine-related drugs do work for many people with RLS, yet some lose benefit and require ever-higher doses. If the dose is too high, medication can aggravate symptoms to a state worse than that prior to treatment.

Dr. Richard Allen points out that despite drugs already being available that can reduce glutamate levels in the brain, such as the anticonvulsive drug gabapentin enacarbil (Horizant), they have not been given as a first-line treatment for RLS patients.

Dr. Allen adds that as more is understood about the neurobiology, his findings could apply to some forms of insomnia as well as restless legs syndrome.

Dr. Richard Allen says:

"It's exciting to see something totally new in the field - something that really makes sense for the biology of arousal and sleep."

Written by Sally Burr

See Sally's blog


Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today Visit our restless legs syndrome section for the latest news on this subject.

Allen RP, Barker PB, Horská A and Earley CJ, Neurology, 2013 vol. 80 no. 22, pp2028-2034. Abstract/summary

The study was funded in part by the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (R01 NS075184 and NS044862), the National Institute on Aging (P10-AG21190) and the National Center for Research Resources (M01RR02719).

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Technique to create better anti-cancer agents, arthritis drugs, and more

Main Category: Lymphoma / Leukemia / Myeloma
Also Included In: Medical Devices / Diagnostics;  Arthritis / Rheumatology
Article Date: 30 Jul 2013 - 0:00 PDT Current ratings for:
Technique to create better anti-cancer agents, arthritis drugs, and more
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Many drugs such as agents for cancer or autoimmune diseases have nasty side effects because while they kill disease-causing cells, they also affect healthy cells. Now a new study has demonstrated a technique for developing more targeted drugs, by using molecular "robots" to hone in on more specific populations of cells.

"This is a proof of concept study using human cells," said Sergei Rudchenko, Ph.D., director of flow cytometry at Hospital for Special Surgery (HSS) in New York City and a senior author of the study. "The next step is to conduct tests in a mouse model of leukemia." The study, a collaboration between researchers from HSS and Columbia University, is in Advance Online Publication on the website of Nature Nanotechnology.

All cells have many receptors on their cell surface. When antibodies or drugs bind to a receptor, a cell is triggered to perform a certain function or behave in a certain manner. Drugs can target disease-causing cells by binding to a receptor, but in some cases, disease-causing cells do not have unique receptors and therefore drugs also bind to healthy cells and cause "off-target" side effects.

Rituximab (Rituxan, Genentech), for example, is used to treat rheumatoid arthritis, non-Hodgkin's lymphoma and chronic lymphocytic leukemia by docking on CD20 receptors of aberrant cells that are causing the diseases. However, certain immune cells also have CD20 receptors and thus the drug can interfere with a person's ability to mount a fight against infection.

In the new study, scientists have designed molecular robots that can identify multiple receptors on cell surfaces, thereby effectively labeling more specific subpopulations of cells. The molecular robots, called molecular automata, are composed of a mixture of antibodies and short strands of DNA. These short DNA strands, otherwise called oligonucleotides, can be manufactured by researchers in a laboratory with any user-specified sequence.

The researchers conducted their experiments using white blood cells. All white blood cells have CD45 receptors, but only subsets have other receptors such as CD20, CD3, and CD8. In one experiment, HSS researchers created three different molecular robots. Each one had an antibody component of either CD45, CD3 or CD8 and a DNA component. The DNA components of the robots were created to have a high affinity to the DNA components of another robot. DNA can be thought of as a double stranded helix that contains two strands of coded letters, and certain strands have a higher affinity to particular strands than others.

The researchers mixed human blood from healthy donors with their molecular robots. When a molecular robot carrying a CD45 antibody latched on to a CD45 receptor of a cell and a molecular robot carrying a CD3 antibody latched on to a different welcoming receptor of the same cell, the close proximity of the DNA strands from the two robots triggered a cascade reaction, where certain strands were ripped apart and more complementary strands joined together. The result was a unique, single strand of DNA that was displayed only on a cell that had these two receptors.

The addition of a molecular robot carrying a CD8 antibody docking on a cell that expressed CD45, CD3 and CD8 caused this strand to grow. The researchers also showed that the strand could be programmed to fluoresce when exposed to a solution. The robots can essentially label a subpopulation of cells allowing for more targeted therapy. The researchers say the use of increasing numbers of molecular robots will allow researchers to zero in on more and more specific subsets of cell populations. In computer programming language, the molecular robots are performing what is known as an "if yes, then proceed to X function."

"The automata trigger the growth of more strongly complementary oligonucleotides. The reactions occur fast. In about 15 minutes, we can label cells," said Maria Rudchenko, M.S., the first author of the paper and a research associate at Hospital for Special Surgery. In terms of clinical applications, researchers could either label cells that they want to target or cells they want to avoid.

"This is a proof of concept study that it works in human whole blood," said Dr. Rudchenko. "The next step is to test it in animals."

If molecular robots work in studies with mice and eventually human clinical trials, the researches say there are a wide range of possible clinical applications. For example, cancer patients could benefit from more targeted chemotherapeutics. Drugs for autoimmune diseases could be more specifically tailored to impact disease-causing autoimmune cells and not the immune cells that people need to fight infection.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our lymphoma / leukemia / myeloma section for the latest news on this subject.

The study was funded, in part, by the National Institutes of Health, National Science Foundation, and the Lymphoma and Leukemia Foundation.

Other researchers involved with the study are Alesia Dechkovskaia from Hospital for Special Surgery, and Steven Taylor, Ph.D., Payal Pallavi, B.A., Safana Khan, Vincent Butler, M.D., and Milan Stojanovic, Ph.D., from Columbia University. Dr. Stojanovich is also a senior author.

Hospital for Special Surgery

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Sunday, 28 July 2013

Optimists better at regulating stress

Main Category: Anxiety / Stress
Also Included In: Psychology / Psychiatry
Article Date: 25 Jul 2013 - 2:00 PDT Current ratings for:
Optimists better at regulating stress
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It's no surprise that those who tend to see a rose's blooms before its thorns are also better at handling stress. But science has failed to reliably associate optimism with individuals' biological stress response - until now.

New research from Concordia University's Department of Psychology is deepening the understanding of how optimists and pessimists each handle stress by comparing them not to each other but to themselves. Results show that indeed the "stress hormone" cortisol tends to be more stable in those with more positive personalities.

The study, which was recently published in the American Psychological Association's Health Psychology journal, tracked 135 older adults (aged 60+) over six years, and involved collecting saliva samples five times a day to monitor cortisol levels. This age group was selected becauseolder adults often face a number of age-related stressors and their cortisol levels have been shown to increase.

Participants were asked to report on the level of stress they perceived in their day-to-day lives, and self-identify along a continuum as optimists or pessimists. Each person's stress levels were then measured against their own average. Measuring the stress levels against participants' own average provided a real-world picture of how individuals handle stress because individuals can become accustomed to the typical amount of stress in their lives.

Joelle Jobin, a PhD candidate in clinical psychology who co-authored the study with her supervisor Carsten Wrosch and Michael Scheier from Carnegie Mellon University, says "for some people, going to the grocery store on a Saturday morning can be very stressful, so that's why we asked people how often they felt stressed or overwhelmed during the day and compared people to their own averages, then analyzed their responses by looking at the stress levels over many days."

She also notes that pessimists tended to have a higher stress baseline than optimists, but also had trouble regulating their system when they go through particularly stressful situations. "On days where they experience higher than average stress, that's when we see that the pessimists' stress response is much elevated, and they have trouble bringing their cortisol levels back down. Optimists, by contrast, were protected in these circumstances," says Jobin.

While the study generally confirmed the researchers' hypotheses about the relation between optimism and stress, one surprising finding was that optimists who generally had more stressful lives secreted higher cortisol levels than expected shortly after they awoke (cortisol peaks just after waking and declines through the day). Jobin says there are several possible explanations, but also notes that the finding points to the difficulty of classifying these complex hormones as good or bad. "The problem with cortisol is that we call it "the stress hormone", but it's also our 'get up and do things' hormone, so we may secrete more if engaged and focused on what's happening."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our anxiety / stress section for the latest news on this subject.

Associations Between Dispositional Optimism and Diurnal Cortisol in a Community Sample: When Stress Is Perceived as Higher Than Normal. Jobin, Joelle; Wrosch, Carsten; Scheier, Michael F. Health Psychology, May 13 , 2013, doi: 10.1037/a0032736

Further information on Carsten Wrosch.

Concordia University

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Understanding the strength of the mussels' underwater attachments could enable better glues and biomedical interfaces

Main Category: Medical Devices / Diagnostics
Article Date: 25 Jul 2013 - 1:00 PDT Current ratings for:
Understanding the strength of the mussels' underwater attachments could enable better glues and biomedical interfaces
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Unlike barnacles, which cement themselves tightly to the surfaces of rocks, piers or ships, the clamlike bivalves called mussels dangle more loosely from these surfaces, attached by a collection of fine filaments known as byssus threads. This approach lets the creatures drift further out into the water, where they can absorb nutrients - although in the process, it exposes them to the risk of being torn away by the force of crashing waves.

But that almost never happens.

Despite the outwardly thin and fragile appearance of these threads, it turns out that in the dynamic, sloshing environment of waves and currents they can withstand impact forces that are nine times greater than the forces exerted by stretching in only one direction.

The secret to these tiny natural bungee cords has now been unraveled by MIT research scientist Zhao Qin and professor of civil and environmental engineering Markus Buehler. Their findings appear this week in the journal Nature Communications.

Byssus threads, they found, are composed of a well-designed combination of soft, stretchy material on one end and much stiffer material on the other. Both materials, despite their different mechanical properties, are made of a protein closely related to collagen, a main constituent of skin, bone, cartilage and tendons.

The team combined computer modeling and laboratory tests on the threads. To carry out their experiments, they placed an underwater cage in Boston Harbor for three weeks, during which time mussels attached themselves to the surfaces of glass, ceramics, wood and clay in the cage. Back in the lab, the mussels, threads and substrates were mounted in a tensile machine designed to test their strength by pulling on them with controlled deformation and recording the applied force during deformation.

"Many researchers have studied mussel glue before," Qin says, referring to the sticky substance that anchors byssus threads to a surface. But the static strength of the glue, and of the thread itself, "is not sufficient to withstand the impact by waves," he says. It's only by measuring the system's performance in simulated wave conditions that he and Buehler could determine how it accomplishes its amazing tenacity.

"We figured there must be something else going on," says Buehler, who heads MIT's Department of Civil and Environmental Engineering. "The adhesive is strong, but it's not sufficient."

The distribution of stiffness along the threads is key, Qin and Buehler found, suggesting that the distribution of intrinsic material properties and the overall architecture of the mussel attachment are important.

The distribution of stiffness in the mussels' threads enables them to be subjected to very large impact forces from waves. About 80 percent of the length of the byssus threads is made of stiff material, while 20 percent is softer and stretchier. This precise ratio may be critical, the researchers found: The soft and stretchy portions of the threads attach to the mussel itself, while the stiffer portion attaches to the rock. "It turns out that the ... 20 percent of softer, more extensible material is critical for mussel adhesion," Qin says.

In their simulations, Qin and Buehler systematically tested other ratios of the material composition and found that the 80-20 ratio of stiff to soft leads to the smallest reaction force. Having more of the softer material increases the reaction force because the material cannot effectively slow down deformation. Moreover, having more stiff material in byssus threads has other advantages, as it prevents the mussels from being pulled too far out by waves, which "would make it easier to hit other objects" and be damaged, Qin says.

These findings, Qin and Buehler say, could help in the design of synthetic materials that share some of these properties. For example, surgical sutures used in blood vessels or intestines are subjected to pulsating or irregular flows of liquid; the use of materials that combine stiffness and stretchiness, as byssus threads do, might provide advantages. The researchers say there may also be applications for materials to attach instruments to buildings, or sensors to underwater vehicles or sensing equipment in extreme conditions.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our medical devices / diagnostics section for the latest news on this subject.

Written by David Chandler, MIT News Office

Massachusetts Institute of Technology

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Sunday, 21 July 2013

New class of white blood cells discovered; potential target for better vaccine design

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our immune system / vaccines section for the latest news on this subject.

The research findings described in this media release can be found in the 23 May issue of Immunity under the title, "IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses" by Andreas Schlitzer1*, Naomi McGovern2*, Pearline Teo1, Teresa Zelante1, Koji Atarashi3, Donovan Low1, Adrian W.S. Ho1, Peter See1, Amanda Shin1, Pavandip Singh Wasan1, Guillaume Hoeffel1, Benoit Malleret1, Alexander Heiseke4, Samantha Chew1, Laura Jardine2, Harriet A. Purvis2, Catharien M.U. Hilkens2, John Tam5,6, Michael Poidinger1, E. Richard Stanley7, Anne B. Krug4, Laurent Renia1, Baalasubramanian Sivasankar8, Lai Guan Ng1, Matthew Collin2, Paola Ricciardi-Castagnoli1, Kenya Honda3, Muzlifah Haniffa2 and Florent Ginhoux1

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648, Singapore. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. II Medical Department, Klinikum Rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. National University Hospital, 119074, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore. Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore.

*These authors contributed equally to this work

Full text of the article can be accessed here

Agency for Science, Technology and Research (A*STAR), Singapore

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Friday, 12 July 2013

Animal Study Finds Estrogen Enables Females To Respond Better To Stress

Main Category: Anxiety / Stress
Also Included In: Women's Health / Gynecology;  Psychology / Psychiatry
Article Date: 11 Jul 2013 - 1:00 PDT Current ratings for:
Animal Study Finds Estrogen Enables Females To Respond Better To Stress
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The idea that females are more resilient than males in responding to stress is a popular view, and now University at Buffalo researchers have found a scientific explanation. The paper describing their study is published online in the high-impact journal, Molecular Psychiatry.

"We have examined the molecular mechanism underlying gender-specific effects of stress," says senior author Zhen Yan, PhD, a professor in the Department of Physiology and Biophysics in the UB School of Medicine and Biomedical Sciences. "Previous studies have found that females are more resilient to chronic stress and now our research has found the reason why."

The research shows that in rats exposed to repeated episodes of stress, females respond better than males because of the protective effect of estrogen. In the UB study, young female rats exposed to one week of periodic physical restraint stress showed no impairment in their ability to remember and recognize objects they had previously been shown. In contrast, young males exposed to the same stress were impaired in their short-term memory.

An impairment in the ability to correctly remember a familiar object signifies some disturbance in the signaling ability of the glutamate receptor in the prefrontal cortex, the brain region that controls working memory, attention, decision-making, emotion and other high-level "executive" processes.

Last year, Yan and UB colleagues published in Neuron a paper showing that repeated stress results in loss of the glutamate receptor in the prefrontal cortex of young males.

The current paper shows that the glutamate receptor in the prefrontal cortex of stressed females is intact. The findings provide more support for a growing body of research demonstrating that the glutamate receptor is the molecular target of stress, which mediates the stress response. The stressors used in the experiments mimic challenging and stressful, but not dangerous, experiences that humans face, such as those causing frustration and feelings of being under pressure, Yan says.

By manipulating the amount of estrogen produced in the brain, the UB researchers were able to make the males respond to stress more like females and the females respond more like males.

"When estrogen signaling in the brains of females was blocked, stress exhibited detrimental effects on them," explains Yan. "When estrogen signaling was activated in males, the detrimental effects of stress were blocked.

"We still found the protective effect of estrogen in female rats whose ovaries were removed," says Yan. "It suggests that it might be estrogen produced in the brain that protects against the detrimental effects of stress." In the current study, Yan and her colleagues found that the enzyme aromatase, which produces estradiol, an estrogen hormone, in the brain, is responsible for female stress resilience. They found that aromatase levels are significantly higher in the prefrontal cortex of female rats.

"If we could find compounds similar to estrogen that could be administered without causing hormonal side effects, they could prove to be a very effective treatment for stress-related problems in males," she says. She notes that while stress itself is not a psychiatric disorder, it can be a trigger for the development of psychiatric disorders in vulnerable individuals.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our anxiety / stress section for the latest news on this subject.

Jing Wei, PhD, postdoctoral associate in the UB Department of Physiology and Biophysics, is first author and Eunice Y. Yuen, PhD, former research assistant professor in the same department, contributed equally. Other co-authors are Xiangning Li, PhD, postdoctoral associate, and Ping Zhong, PhD, research scientist in the same department; Ilia N. Karatsoreos of Washington State University; and Bruce S. McEwen of Rockefeller University.

The research was funded by the National Institute of Mental Health of the National Institutes of Health.

University at Buffalo

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