Manufacture of pharmaceuticals and other compounds could be streamlined by chemical reaction

Main Category: Pharma Industry / Biotech Industry
Article Date: 25 Jul 2013 - 0:00 PDT Current ratings for:
Manufacture of pharmaceuticals and other compounds could be streamlined by chemical reaction

Researchers at The University of Texas at Austin have discovered a new chemical reaction that has the potential to lower the cost and streamline the manufacture of compounds ranging from agricultural chemicals to pharmaceutical drugs.

The reaction resolves a long-standing challenge in organic chemistry in creating phenolic compounds from aromatic hydrocarbons quickly and cheaply.

Phenolic compounds, or phenols, are broadly used as disinfectants, fungicides and drugs to treat many ailments such as Parkinson's disease. Creating a phenol seems deceptively simple. All it requires is replacing a hydrogen molecule on an aromatic hydrocarbon with an oxygen molecule.

"This is a chemical transformation that is underdeveloped and at the same time pivotal in the production of many chemicals important to life as we know it," said Dionicio Siegel, an assistant professor of chemistry in the College of Natural Sciences at The University of Texas at Austin.

The secret that Siegel and his colleagues discovered is a substance called phthaloyl peroxide. This chemical was studied in the late 1950s and early 1960s, but it has been largely ignored during the intervening years.

The scientists were conducting basic studies on phthaloyl peroxide, building on previous research, and decided to use it to tackle the age-old problem of transforming aromatic hydrocarbons into phenols.

The advantage to using phthaloyl peroxide is that the reaction does not require the use of acids or catalysts to work, and it can add oxygen to a wide variety of starting materials.

"There are no special conditions," said Siegel. "You just combine the reagents, mix them and go. It's very simple and straight forward."

The paper describing this discovery was published recently in Nature.

The new process can be applied to other problems in organic chemistry. One particular area of interest is creating metabolites to drugs. Metabolites are the products left after the body finishes breaking down, or metabolizing, a substance. When testing drugs, scientists need to take into account not just how the drug itself reacts in the body, but also how the metabolites react.

"We've had a long-standing interest in accessing metabolites of drugs or compounds that are used in biological systems," said Siegel. "Just as it's important that the drug doesn't have deleterious side effects, it's equally important that the metabolite doesn't have an effect. You need to be able to test them, and there's not really a direct way to access metabolites other than using liver microsomes, and that's not efficient and it doesn't always work."

Another area where Siegel and his colleagues are applying what they have learned is in developing even more reactive agents that will expand the scope of chemicals that can be transformed. Siegel hopes to get this new process into the hands of others quickly. He is working with chemical supply companies to market the phthaloyl peroxide compound and/or the precursors and make it available to people in research and the pharmaceutical industry.

"It hasn't even come out yet," said Siegel, "but there are a lot of people that are already picking up the technique and working on it."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pharma industry / biotech industry section for the latest news on this subject.

Siegel is a co-author on the paper, along with his graduate student, Changxia Yuan, and two undergraduate researchers, Taylor Hernandez and Adrian Berriochoa. Two other co-authors, Kendall Houk and Yong Liang, are from the University of California, Los Angeles.

University of Texas at Austin

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Acetaminophen Overdose Survivors Suffer Poorer Health Than Other Liver Failure Patients

Main Category: Liver Disease / Hepatitis
Also Included In: Alcohol / Addiction / Illegal Drugs;  Psychology / Psychiatry
Article Date: 11 Jul 2013 - 1:00 PDT Current ratings for:
Acetaminophen Overdose Survivors Suffer Poorer Health Than Other Liver Failure Patients

Spontaneous survivors of acetaminophen overdose have significantly lower overall health compared to survivors or transplant recipients following acute liver failure caused by non-drug induced liver injury according to a new study published online in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. Findings show that acetaminophen overdose survivors report more days of impaired mental and physical health, and activity limitations due to poor health, pain, anxiety and depression.

Patients are diagnosed with acute liver failure (ALF) when severe liver dysfunction occurs, along with blood clotting or bleeding disorders (coagulopathy) and compromised brain function (encephalopathy). Studies report that up to 3,000 patients develop ALF in the U.S. each year and 67% of these patients will survive, but nearly 30% of these patients require emergency liver transplantation. However, long-term consequences of ALF and health-related quality of life (HRQOL) of survivors, remains unclear.

To expand understanding of the quality of life and function of adult ALF survivors, a team led by Dr. Robert Fontana from the University of Michigan Medical Center in Ann Arbor conducted a prospective observational study. Patients diagnosed with ALF between January 1998 and July 2010 were included in the study. Participants agreed to follow-up at one and two years following ALF.

Results show that of the 282 ALF patients -125 liver transplantation recipients (10.7% due to acetaminophen overdose) and 157 spontaneous survivors of which 95 were acetaminophen overdose patients and 62 were survivors of non-drug induced liver failure. Patients that survived acetaminophen overdose reported significantly lower general health scores. Acetaminophen overdose survivors had higher rates of substance abuse and psychiatric disease compared to non-acetaminophen overdose survivors and transplant recipients. Participants who were survivors of non-intentional acetaminophen overdose were less likely to have psychiatric comorbidity compared to patients who intentionally overdosed at 48% and 82%, respectively.

The combined group of spontaneous survivors of ALF reported "fair/poor" health and more than 14 days of physical or mental health impairment compared to the general population in the U.S. This group also had more limitation in functional activity due to poor health. "Our findings indicate that adult survivors of ALF have reduced quality of life compared to those of similar age and gender in the general population," concludes Dr. Fontana. "Additional investigations of brain function by our team are underway to further understanding of the type and severity of cognitive impairment reported by ALF survivors."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our liver disease / hepatitis section for the latest news on this subject.

This current study was funded in part by a grant from the National Institute of Diabetes, Digestive and Kidney Diseases (DK U-01-58369) to the United States Acute Liver Failure Study Group (ALFSG), which is led by Dr. William Lee, Professor of Internal Medicine at UT Southwestern Medical Center in Dallas. ALFSG is a National Institutes of Health-funded consortium of investigators in the United States focused on studying acute liver failure.

Full citation: "Quality of Life is Significantly Impaired in Long-Term Survivors of Acute Liver Failure and Particularly In Acetaminophen Overdose Patients." Amol S. Rangnekar, Caitlyn Ellerbe, Valerie Durkalski, Brendan McGuire, William M. Lee and Robert J. Fontana. Liver Transplantation; (DOI: 10.1002/lt.23688) Published Online: June 18, 2013.

URL: http://doi.wiley.com/10.1022/lt.23688

Wiley Please use one of the following formats to cite this article in your essay, paper or report:

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'Acetaminophen Overdose Survivors Suffer Poorer Health Than Other Liver Failure Patients'

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There’s a Black Market for Botox & Other Things to Know Before Getting Injected

Botox might take years off your appearance, but before requesting your own injectable Fountain of Youth, make sure you know exactly what you're doing

By Kristin Booker - June 11, 2013

Botox Might Not Do What You Want It to
Many people confuse what Botox actually does with other age-fighting beauty injectables. “[Botox's] only benefit is to render a muscle weaker for 3-4 months. It doesn't fill lines, it just makes it harder to make the muscle contraction that creates the lines,” explains board-certified dermatologist Dr. Misbah Khan, owner of M. Khan Dermatology in New York City. So will it work on those wrinkles around the mouth? “No. If you have smile lines [the parentheses around the mouth], you'll need a filler [like Restylane] to erase them.”

There's a Black Market
Many coupon services run deals for cheap series of Botox, and they’re probably all too good to be true. Before you buy into anything, know who and what you’re dealing with. “Do not look for the better deal. Make sure you know what’s going in your face. If it's too cheap, it may be acquired on the black market, or the Botox they’re using might be expired or about to expire," warns Dr. Khan.

You Could Have an Allergic Reaction
You may know that Botox is derived from the same bacteria as the toxin botulism, and while you absolutely cannot catch botulism from the use of Botox, there is a small chance that you could have an allergic reaction to preservatives and ingredients used. "Some reactions that have been reported include itching, rash, welts, asthma symptoms or feeling faint,” says Dr. Dennis Gross, founder of 900 5th Dermatology and creator of Dr. Dennis Gross Skincare. If you do have a reaction, call your doctor right away.

An Unskilled Injector Might Leave You Lopsided
“If the Botox is injected wrong in any part of your face, you may have a lopsided appearance,” says Dr. Gross. “Just remember that there is an artistry involved in the technique, so be sure your physician is highly experienced and skilled at administering it.”

Overdoing It Could Lead to Drooping—or Worse
“Drooping of the eyebrows can happen even in the best of hands; it can occur if too much is injected in one place,” says Dr. Khan. And if you’re already using Botox, over-application could make it worse. “Overuse of Botox can cause the muscles to become so weak that they can't support the flesh.” The results can look unnatural, and even worse, be painful. “If too much Botox is applied during a neck rejuvenation, it can cause the side of the face to droop, or in some cases the muscles that hold the neck up weaken to the point where you can't swallow or hold your head up."

Speaking Up Can Divert Disaster
You might think that you really, really want Botox no matter the small risks, but the pursuit of beauty is never worth harming your health. As with any other procedure, you should always disclose your full medical history before sitting in the chair. “Make sure to tell your doctor about all of your muscle or nerve conditions, as you may have an increased risk of serious side-effects, including difficulty swallowing and/or breathing,” cautions Dr. Gross. “Also, inform your doctor of any surgery plans, weakness of forehead muscles, recent injections, or medicines you are currently taking.” Dr. Gervaise Gerstner, L’Oréal Paris Consulting Dermatologist adds one more caution to that list: “Be sure to disclose any autoimmune neuromotor disease like myasenthia gravis.”

Results Are Not Instant
“It takes about three to seven days to show the full effect, and results will last about four months,” says Dr. Gross. And those results vary, depending on the depth of your wrinkles. “If you start Botox treatments just as fine lines are beginning to appear and continue them as you age, you can prevent select expression lines from forming at all,” advises Dr. Gross. Patients who already have pronounced lines may see benefits in a bit more time, “It takes a few days to see results, and a full two weeks to see the full effects of a Botox treatment,” explains Dr. Khan.

Botox is Not Painless
Although getting Botox is not particularly painful for most patients, since there are needles involved, you can’t expect to feel absolutely nothing when getting injected. “During the procedure, you can expect a slight pinch from the needle. There are numbing creams available in topical and aesthetic forms,” says Dr. Gross. Dr. Khan is also known to use ice to numb the area for people who have a low tolerance or phobia of needles.

Aspirin and Fish Oil Don't Mix With Botox
“We tell our patients to stop using aspirin products up to a week before a treatment because they are blood thinners,” cautions Dr. Gross. "Discontinuing the use of aspirin the week before will help to keep bruising down. Also, we tell our patients to stop using fish oils a week beforehand because they also promote bruising for the same blood thinning reason.” Of course, always discuss changing the dosage of medicine with your primary physician beforehand.

Hair-Drying Is Off Limits Right After the Procedure
“There’s no lowering of the head for two hours post-procedure,” says Dr. Gerstner. “No yoga, no bending over, no blow drying your hair, no tight hats, no napping. In other words, heads up!”

It Might Cure More Than Wrinkles
If you have excessive underarm or palm sweating or suffer from serious migraines, talk to your doctor about using Botox to cure these ills. It's been proven to diminish or stop excessive sweating, called hyperhidrosis, and to reduce the severity of migraines too—but don’t try tacking either treatment onto your cosmetic visit. You’ll need to book separate appointments. One quick tip: always take a quick peek at the box. “Botox meant for cosmetic purposes will say ‘Botox Cosmetic’ on the packaging,” says Dr. Khan. “Botox for medical purposes will say that on the package.”

A Happier Look Might Actually Improve Your Mood
If you’re prone to frowning, “eventually those muscles strengthen in that formation, which means it takes much effort to smile and look happy. When Botox relaxes those muscles, you look happier, which can really improve your mood and confidence,” says Dr. Gross.

Kristin Booker is a contributing writer on iVillage. Follow her on Twitter andGoogle+.

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There’s a Black Market for Botox & Other Things to Know Before Getting Injected

Botox might take years off your appearance, but before requesting your own injectable Fountain of Youth, make sure you know exactly what you're doing

By Kristin Booker - June 11, 2013

Botox Might Not Do What You Want It to
Many people confuse what Botox actually does with other age-fighting beauty injectables. “[Botox's] only benefit is to render a muscle weaker for 3-4 months. It doesn't fill lines, it just makes it harder to make the muscle contraction that creates the lines,” explains board-certified dermatologist Dr. Misbah Khan, owner of M. Khan Dermatology in New York City. So will it work on those wrinkles around the mouth? “No. If you have smile lines [the parentheses around the mouth], you'll need a filler [like Restylane] to erase them.”

There's a Black Market
Many coupon services run deals for cheap series of Botox, and they’re probably all too good to be true. Before you buy into anything, know who and what you’re dealing with. “Do not look for the better deal. Make sure you know what’s going in your face. If it's too cheap, it may be acquired on the black market, or the Botox they’re using might be expired or about to expire," warns Dr. Khan.

You Could Have an Allergic Reaction
You may know that Botox is derived from the same bacteria as the toxin botulism, and while you absolutely cannot catch botulism from the use of Botox, there is a small chance that you could have an allergic reaction to preservatives and ingredients used. "Some reactions that have been reported include itching, rash, welts, asthma symptoms or feeling faint,” says Dr. Dennis Gross, founder of 900 5th Dermatology and creator of Dr. Dennis Gross Skincare. If you do have a reaction, call your doctor right away.

An Unskilled Injector Might Leave You Lopsided
“If the Botox is injected wrong in any part of your face, you may have a lopsided appearance,” says Dr. Gross. “Just remember that there is an artistry involved in the technique, so be sure your physician is highly experienced and skilled at administering it.”

Overdoing It Could Lead to Drooping—or Worse
“Drooping of the eyebrows can happen even in the best of hands; it can occur if too much is injected in one place,” says Dr. Khan. And if you’re already using Botox, over-application could make it worse. “Overuse of Botox can cause the muscles to become so weak that they can't support the flesh.” The results can look unnatural, and even worse, be painful. “If too much Botox is applied during a neck rejuvenation, it can cause the side of the face to droop, or in some cases the muscles that hold the neck up weaken to the point where you can't swallow or hold your head up."

Speaking Up Can Divert Disaster
You might think that you really, really want Botox no matter the small risks, but the pursuit of beauty is never worth harming your health. As with any other procedure, you should always disclose your full medical history before sitting in the chair. “Make sure to tell your doctor about all of your muscle or nerve conditions, as you may have an increased risk of serious side-effects, including difficulty swallowing and/or breathing,” cautions Dr. Gross. “Also, inform your doctor of any surgery plans, weakness of forehead muscles, recent injections, or medicines you are currently taking.” Dr. Gervaise Gerstner, L’Oréal Paris Consulting Dermatologist adds one more caution to that list: “Be sure to disclose any autoimmune neuromotor disease like myasenthia gravis.”

Results Are Not Instant
“It takes about three to seven days to show the full effect, and results will last about four months,” says Dr. Gross. And those results vary, depending on the depth of your wrinkles. “If you start Botox treatments just as fine lines are beginning to appear and continue them as you age, you can prevent select expression lines from forming at all,” advises Dr. Gross. Patients who already have pronounced lines may see benefits in a bit more time, “It takes a few days to see results, and a full two weeks to see the full effects of a Botox treatment,” explains Dr. Khan.

Botox is Not Painless
Although getting Botox is not particularly painful for most patients, since there are needles involved, you can’t expect to feel absolutely nothing when getting injected. “During the procedure, you can expect a slight pinch from the needle. There are numbing creams available in topical and aesthetic forms,” says Dr. Gross. Dr. Khan is also known to use ice to numb the area for people who have a low tolerance or phobia of needles.

Aspirin and Fish Oil Don't Mix With Botox
“We tell our patients to stop using aspirin products up to a week before a treatment because they are blood thinners,” cautions Dr. Gross. "Discontinuing the use of aspirin the week before will help to keep bruising down. Also, we tell our patients to stop using fish oils a week beforehand because they also promote bruising for the same blood thinning reason.” Of course, always discuss changing the dosage of medicine with your primary physician beforehand.

Hair-Drying Is Off Limits Right After the Procedure
“There’s no lowering of the head for two hours post-procedure,” says Dr. Gerstner. “No yoga, no bending over, no blow drying your hair, no tight hats, no napping. In other words, heads up!”

It Might Cure More Than Wrinkles
If you have excessive underarm or palm sweating or suffer from serious migraines, talk to your doctor about using Botox to cure these ills. It's been proven to diminish or stop excessive sweating, called hyperhidrosis, and to reduce the severity of migraines too—but don’t try tacking either treatment onto your cosmetic visit. You’ll need to book separate appointments. One quick tip: always take a quick peek at the box. “Botox meant for cosmetic purposes will say ‘Botox Cosmetic’ on the packaging,” says Dr. Khan. “Botox for medical purposes will say that on the package.”

A Happier Look Might Actually Improve Your Mood
If you’re prone to frowning, “eventually those muscles strengthen in that formation, which means it takes much effort to smile and look happy. When Botox relaxes those muscles, you look happier, which can really improve your mood and confidence,” says Dr. Gross.

Kristin Booker is a contributing writer on iVillage. Follow her on Twitter andGoogle+.

Connect with Us Follow Our Pins

Yummy recipes, DIY projects, home decor, fashion and more curated by iVillage staffers.

The very dirty truth about fashion internships... DUN DUN @srslytheshow http://t.co/wfewf

On Instagram

Behind-the-scenes pics from iVillage.

View the original article here