Also Included In: Obesity / Weight Loss / Fitness; Heart Disease; Genetics
Article Date: 13 Jul 2013 - 0:00 PDT Current ratings for:
The Obese Are At Increased Risk For Heart Disease When Exposed To Cigarette Smoke
New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study, published in ACS' Chemical Research in Toxicology, suggests that the effects may be especially profound in obese nonsmokers who inhale "sidesteam smoke" from cigarettes smoldering nearby.
Diana J. Bigelow and colleagues point out that active smoking doubles the risk of heart disease, while second-hand smoke exposure increases this risk by about one-third. They set out to gain more information on why the risks are especially high among people with obesity, using specially fed laboratory mice that are stand-ins for humans in such experiments.
The report describes how mainstream smoke and to a greater extent, sidestream smoke, inhibit the activity of genes that protect the heart and lungs, and activate genes associated with an increased risk of heart disease. Those changes were more profound in obese mice than normal-weight mice. "The present study is the first, to our knowledge, that addresses the in vivo transcriptional response of the heart to cigarette smoke exposure in the setting of high fat diet and obesity, and thus takes a first step toward identifying the molecular basis of adaptive responses that may lead to an increased risk of heart disease in obese smokers," the report states.
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.Visit our smoking / quit smoking section for the latest news on this subject.
The authors acknowledge funding from the Exposure Biology Program in the National Institute of Environmental Health Sciences, part of the National Institutes of Health.
American Chemical Society
Please use one of the following formats to cite this article in your essay, paper or report:MLA
14 Jul. 2013.
Please note: If no author information is provided, the source is cited instead.
posted by miki mario on 14 Jul 2013 at 2:29 pm
New insights into why obese cigarette smokers experience a high risk of heart disease suggest that cigarette smoke affects the activity of hundreds of key genes that both protect the heart and lungs and expose them to damage. The study, published in ACS’ Chemical Research in Toxicology, suggests that the effects may be especially profound in obese nonsmokers who inhale “sidesteam smoke” from cigarettes smoldering nearby.
| post followup | alert a moderator |
'The Obese Are At Increased Risk For Heart Disease When Exposed To Cigarette Smoke'
Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.
If you write about specific medications or operations, please do not name health care professionals by name.
All opinions are moderated before being included (to stop spam)
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
No comments:
Post a Comment