New drug targets discovered for aggressive breast cancer

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Research publication: The research findings described in the press release was published in the July 2nd, 2013 issue of PNAS (Proceedings of the National Academy of Sciences, USA) under the title “Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis”.

Authors: Shuet Theng Leea,1, Min Fenga,1, Yong Weib,1, Zhimei Lia, Yuanyuan Qiaoa, Peiyong Guanc, Xia Jianga, Chew Hooi Wonga, Kelly Huynhd, Jinhua Wangd, Juntao Lic, K. Murthy Karuturic, Ern Yu Tane, Dave S. B. Hoond, Yibin Kangb, and Qiang Yua,f,g*

a. Cancer Biology and Pharmacology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672;

b. Department of Molecular Biology, Princeton University, Princeton, NJ 08544;

c. Information and Mathematical Science, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672;

d. Department Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404;

e. Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433;

f. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and

g. Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore

1. These authors contributed equally to this study.

* Correspondance: Qiang Yu, yuq@gis.a-star.edu.sg. Tel: (65)6808-8127

[1] Protein tyrosine phosphatases, are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. These enzymes are key regulatory components in signal transduction pathways and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation. (https://en.wikipedia.org/wiki/Protein_tyrosine_phosphatase)

Agency for Science, Technology and Research (A*STAR), Singapore

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